Establishing Patient-Derived IDH Mutant Astrocytoma Organoid Biobank for Personalized Therapy

Dr. Haikun Liu

Dr. Miriam Ratliff

German Cancer Research Center, Heidelberg
University Hospital Heidelberg

Project Summary:
This project aims to build a biobank of mini-tumors (called organoids) grown from patients with a specific type of brain tumor known as IDH-mutant astrocytoma. These organoids are created using a method that preserves the original tumor’s structure and immune cells, allowing researchers to better mimic the patient’s disease in the lab. By testing different drugs on these organoids, scientists hope to identify which treatments work best for each individual patient. The project also includes detailed genetic and cellular analysis to ensure that the organoids closely match the original tumors. Ultimately, this research will support more personalized and effective therapies for people with IDH-mutant brain tumors.

Expected Project Timeframe: September 2025 to August 2027